PRODUCT DETAILS

About Atrmin 250mg Capsule

PENICILLAMINE belongs to the group of medicines called ‘chelating agent’ used to treat severe rheumatoid arthritis, Wilsons disease, cystinuria. Rheumatoid arthritis is a joint disorder in which our immune system attacks our own body cells. Wilson disease is a genetic problem characterized by excess copper deposited in body parts like eye, brain and liver leading to metal toxicity. Cystinuria is the excess build-up of an amino acid called cystine in the urinary bladder and kidney, leading to harmful effect. 

PENICILLAMINE contains Penicillamine that works by blocking the action of certain chemical messengers responsible for inflammation and slows the progress of the condition with certain joint diseases. It works in Wilson's disease by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function, mental, mood, and nerve problems (like confusion, difficulty speaking or walking) caused due to Wilson's disease. Besides this, PENICILLAMINE also used to treat cystinuria (kidney and bladder stone) and lead poisoning.

Uses of Atrmin 250mg Capsule

Rheumatoid arthritis, Wilson's disease, Cystinuria, Lead poisoning

Medicinal Benefits of Atrmin 250mg Capsule

PENICILLAMINE contains Penicillamine primary used to treat Wilson's disease (copper to build up in the body and may result in serious symptoms) and cystinuria (kidney stones). It is also used in combination with other treatments to treat severe rheumatoid arthritis. The treatment of rheumatoid arthritis PENICILLAMINE reduces pain, inflammation, and slow joint damage and disease progression over time; hence PENICILLAMINE is known as a disease-modifying anti-rheumatic drug (DMARD). In Wilson's disease, PENICILLAMINE works by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function and the mental, mood, nerve problems (such as confusion, difficulty speaking/walking) caused by Wilson's disease. In cystinuria, it helps decrease the amount of a certain substance (cystine) by binding to that substance which can cause kidney stones and preventing it from building up and forming stones. Besides this, PENICILLAMINE also used to treat lead poisoning.

Directions for Use

PENICILLAMINE is available in capsule and tablet form. Tablet/Capsule: PENICILLAMINE is usually taken on an empty stomach at least 1 hour before or after a meal. Swallow as a whole with a glass of water; do not break, or chew the tablet/capsule. Based on your medical condition, your doctor will prescribe for how long you need to take PENICILLAMINE. Take PENICILLAMINE exactly as prescribed by the doctor.

Side Effects of Atrmin 250mg Capsule

• Protein in urine
• Low blood platelets
• Stomach upset 
• Diarrhoea
• Change in taste
• Loss of appetite
• Mouth irritation
• Mouth sores

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

Do not take PENICILLAMINE if you are allergic (hypersensitive) to penicillamine or any of the other ingredients in it. Inform your doctor if you have severe kidney problems, lupus erythematosus (an auto-immune disorder), agranulocytosis (a low white cell blood count), aplastic anaemia (symptoms include feeling tired, breathless, having pale skin and more susceptible to infection) or thrombocytopenia (a blood disorder which causes bleeding into your skin, bruising and bleeding more than normal). Do not take PENICILLAMINE if you are pregnant or planning to get pregnant and breastfeeding. This medicine may cause harm to the unborn baby if you take it while you are pregnant. Caution should be required while taking PENICILLAMINE by elderly patients as they may be at greater risk of suffering side-effects if you are taking PENICILLAMINE over a long time, especially if you are on a restricted diet, as this medicine increases the requirement for pyridoxine (Vitamin B6) so your doctor may also prescribe this vitamin for you. If you are taking iron tablets, antacids or digoxin (used to treat heart failure), please maintain two hours gap between these tablets and PENICILLAMINE. Low blood cell counts have happened while taking PENICILLAMINE. If blood cell counts get very low, this can lead to bleeding problems, infections, or anaemia, and sometimes, these have been deadly. 

Drug Interactions

Drug-Drug Interaction:

 PENICILLAMINE interacts with medicine used to treat low iron levels or anaemia (carbonyl iron, heme iron polypeptide), medicine used to treat rheumatoid arthritis (gold sodium thoimalate, auranofin, aurothioglucose), a medicine used to treat heart conditions (digoxin), antacids (aluminium hydroxide, aluminium carbonate), non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indomethacin, naproxen, oxyphenbutazone, phenylbutazone), anti-malarial agents (chloroquine, hydroxychloroquine), the medicine used to treat the mental illness schizophrenia (clozapine), a medicine used in the treatment of Parkinson's disease (levodopa) medicines to treat cancers(azathioprine, cyclophosphamide),  immunosuppressive drugs (mycophenolate, cyclosporine), and zinc.

Drug-Disease Interaction:

PENICILLAMINE should not be used in people with bone marrow suppression, kidney dysfunction, liver disease, anaemia, asthma and allergies.

Safety Advice

ALCOHOL

You are recommended to avoid alcohol consumption while taking PENICILLAMINE. It could lead to increased dizziness and drowsiness.

PREGNANCY

PENICILLAMINE is a pregnancy category D drug. It is not recommended to take PENICILLAMINE while you are pregnant. PENICILLAMINE may cause serious birth defects.

BREAST FEEDING

PENICILLAMINE should not be used in breastfeeding mothers as PENICILLAMINE passes into breast milk.

DRIVING

PENICILLAMINE may cause dizziness, drowsiness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

LIVER

PENICILLAMINE is not recommended for the liver patients.

KIDNEY

PENICILLAMINE should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.